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Archive for the ‘Hyperthyroidism’ Category

Hyperthyroidism Therapy Area Pipeline Report contains detailed information on the hyperthyroidism drug pipeline. This report provides insight into the pipeline status of hyperthyroidism drugs by company and by stage as well as a summary of the latest news and developments in this area.

Scope of the report:

Each Life Science Analytics Therapy Area Pipeline Report provides the user with real detail on drug pipelines, by company and by stage, for each specific therapy area. The latest news, by company, also ensures that each report is fresh and up-to-date.

In addition to new developments and disease specific pipeline projects, each report also contains extensive information in tabular format on a companys full product pipeline and products by phase of development with regard to the therapy area.

Full pipeline details, by stage, are provided and include detailed product descriptions, information on partnering activity plus clinical trial intelligence. Each Therapy Area Pipeline Report also provides detail on the top 20 companies with products in the early stage of development and the top 20 companies with products in the late stage of development. Finally, each report also provides a comparison with other major indications in the disease hub based on Marketed Products vs. Pipeline Products.

Key benefits

Understand a companys strategic position by accessing detailed independent intelligence on its product pipeline for specific therapy areas.
Keep track of your competitors and partners by better understanding their product pipeline.
Monitor a companys research effectiveness by determining pipeline depth and number of products in development by clinical phase for specific disease areas.
Maintain a critical competitive advantage.
Table of Contents :
Epidemiology Report
% of Products by Phase of Development
No. of Products by Phase of Development
Marketed Products vs. Pipeline Products
Company Overview – Pipeline Projects
Legend
–Top 5 Companies in Late Stage Hyperthyroidism Products
–Top 5 Companies in Marketed Hyperthyroidism Products
Product Sales
Full Pipeline View
–Product Details : Phase II
–Product Details : On the Market

For more information please visit :

http://www.aarkstore.com/reports/Hyperthyroidism-Therapy-Area-Pipeline-Report-67164.html

From: Aarkstore Enterprise
Contact: Anna
Ph.No.91927282585
Email: winaarkstore@gmail.com
URL:http://www.aarkstore.com/

Everyone who has the cat sick of hyperthyroidism only tries to find out the right treatment and oversees other important factors that can improve the condition. You should ask yourself what to feed your cat if it has feline hyperthyroidism, on a daily basis. That very moment when you realize that your cat is getting old day after day and her health conditions are changing you must take care of her more and give her only the best kind of food. Don’t wait until your cat gets sick, try to keep her healthy as much as possible.

1. Make the food – try to avoid the canned food, because it has so many chemicals that must keep it last for a long time. Some say the soy is the major ingredient in every canned food, and it can cause the hyperthyroidism. It is easy to remember that you must give your cat the poultry and the beef, but many vegetables should be avoided.

If you can’t make the menu by yourself and you are wondering what to feed your cat if it has feline hyperthyroidism, the vet can do the daily plan for you, and you should just stick to it.

2. The remedies – they are not only helpful when your cat is expressing some health problems, they can be a great prevention and increase the quality of your cat’s lifestyle. The chamomile, lemon balm, and bladderwrack are just some of the herbs you can easily find or buy, and you can practically combine it however you want, and put it in the food, as well. Besides, the supplements of vitamins and minerals are “must”, especially for older cats.

3. Stick to the schedule – most cats start losing the weight when they are sick, or they start eating too much or lose appetite, so you should control their food intake.

It is not only about what to feed your cat if it has feline hyperthyroidism; it’s about how to create the balanced meal that will contain all the nutrients your cat needs. That way, you can also be able to notice the symptoms of and changes in your cat’s body.

Today, it is not a problem to find out what to feed your cat if it has feline hyperthyroidism since every vet can give you the best plan, according to your cat’s health condition. The problem is how to make the plan into reality. To be realistic, make people can’t stick to their own diet, so how can we expect more responsibility when it comes to their cat.

Signs and symptoms Major clinical signs include weight loss often accompanied by an increased appetite anxiety intolerance to heat hair loss muscle aches weakness fatigue hyperactivity irritability apathy depression polyuria polydipsia delirium tremor pretibial myxedema and sweating Additionally patients may present with a variety of symptoms such as palpitations and arrhythmias notably atrial fibrillation shortness of breath dyspnea loss of libido nausea vomiting and diarrhea Long term untreated hyperthyroidism can lead to osteoporosis In the elderly these classical symptoms may not be present Neurological manifestations can include tremors chorea myopathy and in some susceptible individuals particularly of Asian descent periodic paralysis An association between thyroid disease and myasthenia gravis has been recognized The thyroid disease in this condition is autoimmune in nature and approximately 5 of patients with myasthenia gravis also have hyperthyroidism Myasthenia gravis rarely improves after thyroid treatment and the relationship between the two entities is not well understood Some very rare neurological manifestations that are dubiously associated with thyrotoxicosis are pseudotumor cerebri amyotrophic lateral sclerosis and a Guillain Barr like syndrome Minor ocular eye signs which may be present in any type of hyperthyroidism are eyelid retraction stare extra ocular muscle weakness and lid lag In hyperthyroid stare Dalrymple sign the eyelids are retracted upward more than normal the normal position is at the superior corneoscleral limbus where the white of the eye begins at the upper border of the iris Extra ocular muscle weakness may present with double vision In lid lag von Graefe s sign when the patient tracks an object downward with their eyes the eyelid fails to follow the downward moving iris and the same type of upper globe exposure which is seen with lid retraction occurs temporarily These signs disappear with treatment of the hyperthyroidism Neither of these ocular signs should be confused with exophthalmos protrusion of the eyeball which occurs specifically and uniquely in hyperthyroidism caused by Graves disease Note that not all exopthalmos is caused by Graves disease but when present with hyperthyroidism is diagnostic of Graves disease This forward protrusion of the eyes is due to immune mediated inflammation in the retro orbital eye socket fat Exophthalmos when present may exacerbate hyperthyroid lid lag and stare Thyrotoxic crisis or thyroid storm is a rare but severe complication of hyperthyroidism which may occur when a thyrotoxic patient becomes very sick or physically stressed Its symptoms can include an increase in body temperature to over 40 degrees Celsius 104 degrees Fahrenheit tachycardia arrhythmia vomiting diarrhea dehydration coma and death Causes Functional thyroid tissue producing an excess of thyroid hormone occurs in a number of clinical conditions The major causes in humans are Graves disease the most common etiology with 70 80 Toxic thyroid adenoma Toxic multinodular goitre High blood levels of thyroid hormones most accurately termed hyperthyroxinemia can occur for a number of other reasons Inflammation of the thyroid is called thyroiditis There are a number of different kinds of thyroiditis including Hashimoto s thyroiditis immune mediated and subacute thyroiditis DeQuervain s These may be initially associated with secretion of excess thyroid hormone but usually progress to gland dysfunction and thus to hormone deficiency and hypothyroidism Oral consumption of excess thyroid hormone tablets is possible as is the rare event of consumption of ground beef contaminated with thyroid tissue and thus thyroid hormone termed hamburger hyperthyroidism Amiodarone an anti arrhythmic drug is structurally similar to thyroxine and may cause either under or overactivity of the thyroid Postpartum thyroiditis PPT occurs in about 7 of women during the year after they give birth PPT typically has several phases the first of which is hyperthyroidism This form of hyperthyroidism usually corrects itself within weeks or months without the need for treatment Diagnosis A diagnosis may be suspected on history and physical examination and is confirmed with blood tests Measuring the level of thyroid stimulating hormone TSH in the blood is usually all that is required A low TSH indicates that the pituitary gland is being inhibited by increased levels of T4 and or T3 in the blood and is therefore a reliable marker of hyperthyroidism Rarely a low TSH indicates primary failure of the pituitary or temporary inhibition of the pituitary due to another illness euthyroid sick syndrome and so checking the T4 and T3 is still clinically useful Measuring specific antibodies such as anti TSH receptor antibodies in Graves disease or anti thyroid peroxidase in Hashimoto s thyroiditis common cause of HYPOthyroidismay also contribute to the diagnosis Thyroid scintigraphy is a useful test to distinguish between causes of hyperthyroidism and this entity from thyroiditis In addition to testing the TSH levels many doctors test for T3 Free T3 T4 and or Free T4 for more detailed results The diagnosis of hyperthyroidism is confirmed by blood tests that show a decreased thyroid stimulating hormone TSH level and elevated T4 and T3 levels TSH is a hormone made by the pituitary gland in the brain that tells the thyroid gland how much hormone to make When there is too much thyroid hormone the TSH will be low A radioactive iodine scan a test that uses injected radioactive iodine to examine the activity of the thyroid gland will show an enlarged thyroid gland that is over functioning Treatment The large and generally accepted modalities for treatment of hyperthyroidism in humans involve initial temporary use of suppressive thyrostatics medication and possibly later use of permanent surgical or radioisotope therapy All approaches may cause under active thyroid function hypothyroidism which is easily managed with levothyroxine supplementation Temporary medical therapy Thyrostatics Thyrostatics are drugs that inhibit the production of thyroid hormones such as carbimazole used in UK and methimazole used in US and propylthiouracil Thyrostatics are believed to work by inhibiting the iodination of thyroglobulin by thyroperoxidase and thus the formation of tetra iodothyronine T4 Propylthiouracil also works outside the thyroid gland preventing conversion of mostly inactive T4 to the active form T3 Because thyroid tissue usually contains a substantial reserve of thyroid hormone thyrostatics can take weeks to become effective and the dose often needs to be carefully titrated over a period of months A very high dose is often needed early in treatment but if too high a dose is used persistently patients can develop symptoms of hypothyroidism Beta blockers Many of the common symptoms of hyperthyroidism such as palpitations trembling and anxiety are mediated by increases in beta adrenergic receptors on cell surfaces Beta blockers are a class of drug which offset this effect reducing rapid pulse associated with the sensation of palpitations and decreasing tremor and anxiety Propranolol has two roles in the treatment of hyperthyroidism determined by the different isomers of propranolol L propranolol causes beta blockade thus treating the symptoms associated with hyperthyroidism such as tremor palpitations anxiety and heat intolerance D propranolol inhibits Thyroxine deiodinase thereby blocking the conversion of T4 to T3 providing some though minimal therapeutic effect Other Beta Blockers are only used to treat the symptoms associated with hyperthyroidism Propranolol in the US and Metoprolol in the UK are most frequently used to augment treatment for hyperthyroid patients Permanent treatments Surgery as an option predates the use of the less invasive radioisotope therapy but is still required in cases where the thyroid gland is enlarged and causing compression to the neck structures or the underlying cause of the hyperthyroidism may be cancerous in origin Surgery Surgery to remove the whole thyroid or a part of it is not extensively used because most common forms of hyperthyroidism are quite effectively treated by the radioactive iodine method and because there is a risk of also removing the parathyroid glands and of cutting the recurrent laryngeal nerve making swallowing difficult However some Graves disease patients who cannot tolerate medicines for one reason or another patients who are allergic to iodine or patients who refuse radioiodine opt for surgical intervention Also some surgeons believe that radioiodine treatment is unsafe in patients with unusually large gland or those whose eyes have begun to bulge from their sockets claiming that the massive dose of iodine needed will only exacerbate the patient s symptoms Radioiodine In iodine 131 Radioiodine radioisotope therapy radioactive iodine 131 is given orally either by pill or liquid on a one time basis to destroy the function of a hyperactive gland Patients who do not respond to the first dose are sometimes given an additional radioactive iodine treatment in a larger dose The iodine given for ablative treatment is different from the iodine used in a scan Radioactive iodine is given after a routine iodine scan and uptake of the iodine is determined to confirm hyperthyroidism The radioactive iodine is picked up by the active cells in the thyroid and destroys them Since iodine is only picked up by thyroid cells and picked up more readily by over active thyroid cells the destruction is local and there are no widespread side effects with this therapy Radioactive iodine ablation has been safely used for over 50 years and the only major reasons for not using it are pregnancy and breast feeding A common outcome following radioiodine is a swing to the easily treatable hypothyroidism and this occurs in 78 of those treated for Graves thyrotoxicosis and in 40

Thyroid is an important gland in the human body. These glands are found on the front side of the neck. The thyroid gland secretes a hormone known as “thyroid hormones”. These hormones have an important part to play in the metabolism process of our body. Metabolism is a process by which the food particles that we take in are converted into energy of different forms which are used to satisfy the different needs of a human body. Hyperthyroidism is a health disorder which happens when thyroid glands produces hormones which is actually more than the body’s requirement. Due to this overproduction of thyroid hormone, our metabolism process gets accelerated and thus it will lead to many health disorders in human beings.

Hyperthyroidism is caused in human beings when the thyroid glands segregate more hormones than what is actually required for the human body. These extra hormones will result in damaging the functional thyroid tissue. Human body treats thyroid hormones as foreign agents as it is the cause of many health disorders. There are some medicines which can result in thyroid glands producing more hormones for the body. So it is always advisable that you should take reasonable care while taking medicines as in many cases it may lead to hormonal imbalances. Lithium, which is given for some psychiatric disorders, is one such type of medicine that may lead to hormonal imbalances in your body.

Hashimoto’s Thyroiditis, is the most common type of hyperthyroidism. It can cause serious damages to our immune system and there are many chances that your body will also be affected. There are many symptoms that can be seen before hyperthyroidism. But some of the major symptoms of this health disorder are weight gain and fatigue. We can easily identify a person with hyperthyroidism as he would be gaining weight all of a sudden once he is affected with hormone imbalances in his body. Every year thousands of women are diagnosed with hyperthyroidism problems. This number of people suffering from hyperthyroidism is fast increasing but even then people do not have much knowledge about the thyroid gland and the hormone imbalances that it can cause in human bodies.

When diagnosed with hyperthyroidism we would search around for the treatment options available to treat this health disorder. There are basically three forms of treatment available for hyperthyroidism. Each of these treatments has their own advantages and limitations. The doctors look into a number of reasons before choosing the type of treatment which is required for a person with hormonal imbalances. All the three treatments available for hyperthyroidism are much effective and you can be sure of a positive result irrespective of the treatment that you chose.

Surgery is not a necessary option for cases with hyperthyroidism. Most surgeons are of the opinion that a radioiodine treatment is much harmful to many patients who have bigger glands. If the hyperthyroidism is an acute one, then a surgery can be conducted so as to cure the patient from this health disorder.

Hyperthyroidism refers to a situation wherein the thyroid gland has an overactive tissue that results in overproduction. This overproduction leads to an excess number of circulating free thyroid hormones. Because the thyroid hormone affects nearly all body cells, the result is that vital functions of the body also overdo their regular functioning.

One of the immediate impacts of hyperthyroidism is an increased heart beat rate, palpitations, ands sweating. Another impact is that it may overstimulate metabolism. In general, hyperthyroidism is more common in women than in men, and is especially common in women ages 20 to 40.

Causes of Hyperthyroidism

The following are the most common causes of hyperthyroidism:

* Inflammation of the thyroid * Oral consumption of thyroid hormone tablets * Malfunctioning or deficiencies in the immune system * Hyperthyroidism may also happen when the body has taken a substance or is producing a substance that causes the thyroid gland to make more hormones than needed by the body. * Due to tumor in the thyroid

Symptoms of Hyperthyroidism

One of the most common symptom of hyperthyroidism is unexplained weight loss. The weight loss is often accompanied by loss of appetite. Apart from these symptoms, the following are also indicators of the disease: * Diarrhea * Goiter or increase in the size of thyroid glands * Fast heart rate or palpitation * Tiredness * Sleeplessness * Anxiety * Experiencing tremors in the body or feeling shaky * Feeling sweaty and hot, especially even in comfortable situations * A shortness of breath * Irritation of the eyes * Nausea and vomiting * Loss of libido or the urge to have sex

Detection of Hyperthyroidism

Detection of hyperthyroidism is an important step toward finding a treatment for the disease. On the other hand, the inability to accurately detect the disease can lead to long-term effects, one of which is osteoporosis.

The following are the means to detect the presence of the disease in a woman:

* Based on family history. This is because the disease may be passed on from parent to offspring and from generation to generation. * By physical examination. Although this is one of the easiest ways to detect the disease, it is often inaccurate in itself so laboratory tests and other supplemental procedures are needed to accurately pinpoint the presence of the disease. * Through blood tests. During blood tests, the level of thyroid-stimulating hormones in the blood is monitored. If the level of the hormone is low, it indicates that something is inhibiting the pituitary glands to produce hormones and thus an indicator for having hyperthyroidism. * Through measurement of specific antibodies.

Treatments for Hyperthyroidism

Hyperthyroidism can be cured through medication, therapy, or surgery, depending on the extent of the disease. When using medication to treat the disease, the most commonly prescribed drug is Thyrostatics. This drug is known to inhibit the production of thyroid hormones. However, the most effective method of treatment is still surgery. In surgeries, the tumor in the thyroid gland is removed.